Endocrine Abstracts

Regulatory peptides are known to have a role in tumour growth. Local peptide concentrations will be affected by their proteolytic release from precursors, together with the rate of their proteolytic degradation. In this study three inhibitors of proteolysis were examined, Captopril, an ACE inhibitor, Thiorphan an inhibitor of Neutral Endopeptidase and Phosphoramidon which inhibits both Neutral Endopeptidase and also Endothelin Converting Enzyme (ECE). The effect of these inhib...

Gross cystic disease of the breast is a condition afflicting 7% of western women and confers an increased risk of developing breast cancer. Biochemical analyses of breast cyst fluid (BCF) have allowed the identification of various components of BCF and the classification of breast cysts into type I and II cysts. Gross cystic disease fluid proteins (GCDFP) are a family of proteins found in BCF and include albumin, apolipoprotein D and prolactin inducible protein (PIP). It is pr...